To explore the connection between lactate and endothelial inflammation in atherosclerosis, we assessed Vcam‐1 and Icam‐1 expression in the aortic endothelium and measured lactate levels in the aortic tissues and blood of Apoe−/− mice and wild‐type (WT) mice that were fed a Western diet (WD) for 1 month. This evidence concerns the gene ICAM1 and atherosclerosis.