APOE and atherosclerosis: To achieve EC‐specific KD of Mct1, immediately after initiating a WD to induce atherosclerosis, Apoe−/− mice were administered DSPE–PEG–PEI/Pep/sictl and DSPE–PEG–PEI/Pep/siMct1 nanoparticles via tail vein injection at biweekly intervals for a total duration of 14 weeks (Figure 7A).