To determine whether Mct1 inhibition could alleviate endothelial inflammation in atherosclerosis, we administered DSPE–PEG–PEI/Pep/sictl and DSPE–PEG–PEI/Pep/siMct1 nanoparticles to Apoe−/− mice fed a WD for 1 month by tail vein injection. The gene discussed is APOE; the disease is atherosclerosis.