Allergic symptoms are often present in chronic helminth infections, caused by a constant state of immune activation characterized by a dominant type of Th2 cytokine profiles and high IgE levels.26,27 However, eosinophilia is not usually seen in helminth infections that reside in the lumen of the human intestine, as is the case withH. diminuta. However, helminth infections can affect the expression of an allergic disease and, in certain situations, may be associated with a higher, lower, or no risk of atopic conditions.28,29. This evidence concerns the gene IGHE and allergic disease.