IL33 and Alzheimer disease: AD is a chronic inflammatory skin condition characterized by itching, redness, and compromised skin barrier function [7], Alarmins including IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) activate type 2 innate lymphoid cells, which release cytokines like IL-4, IL-5, and IL-13, crucial in the pathogenesis of AD [8].