Given the close relationship between NLRP3 inflammasome, IL-1β, and IL-18 and their role in amplifying inflammatory reactions and liver disease progression, we assessed the mRNA and protein levels of NLRP3 inflammasome in liver tissues and cells to explore the connection between geniposide-induced hepatotoxicity and NLRP3 inflammasome. This evidence concerns the gene IL1B and liver disorder.