Melatonin, known for its role in regulating circadian rhythms and sleep, provides antioxidant and anti-inflammatory effects that mitigate AD pathology, including Aβ accumulation and tau hyperphosphorylation (Cardinali et al., 2014; Furio et al., 2007; Hardeland, 2018; Li et al., 2020; Lin et al., 2013; Wade et al., 2014; Xu et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.