We found that a low level of STRA13 autoantibody was correlated with bone metastasis, meanwhile, higher expression of STRA13 mRNA predicts longer survival time in NSCLC, indicating that STRA13 may be a tumor suppressor, whereas, in LUAD, a high level of STRA13 protein somehow predicted poor survival rate. The gene discussed is BHLHE40; the disease is non-small cell lung carcinoma.