MLH1 and neoplasm: In addition to other members of the PCDH family, PCDHGB7 is closely related to proteins such as Protocadherin Fat 1(FAT1), mutL homolog 1(MLH1), and fragile histidine triad diadenosine triphosphatase (FHIT), which have been shown to be involved in DNA mismatch repair and related to tumor stemness (Figure 3A) (23, 24).