CTLA4 and Hepatic fibrosis: For instance, along with the higher T1pre and T1HBP values, coupled with lower Δ% and FLIS values, the progression of liver fibrosis and the decline of liver regeneration capacity could alter hepatic immune microenvironment, leading to the presence of tumor-infiltrating lymphocytes such as CD8+and CD4+T cells, and the upregulation of exhaustion markers such as PD-L1, and CTLA-4 (49, 50).