MRPS7 and Hepatic fibrosis: Accordingly, with the progression of liver fibrosis, the uptake of Gd-EOB-DTPA in hepatocytes would be in decrease and the secretion would be in increase due to the decreasing Oatps expression and the increasing Mrps expression, finally resulting in the significant increase of T1 relaxation times (T1HBP) and the significant decrease of signal enhancement of parenchyma after Gd-EOB-DTPA injection.