STAT3 and neoplasm: Interleukin-6 (IL-6) is an oncogenic mediator of utmost importance that mediates immune and inflammatory responses, activates Signal Transducer and Activator of Transcription 3 (STAT3) in tumor cells, and its effects on oncogenesis, tumor immunosuppression, tumor angiogenesis, and metastasis are well established (82, 83).