MMP9 and lymphoma: In addition, HHT combined with curcumin significantly suppresses the proliferation, migration, and angiogenesis of lymphoma cells by inhibiting the phosphorylation of VEGFR2 and AKT, which reduces the signaling of angiogenin 1 (ANG-1), matrix metalloproteinase 2 (MMP2), and matrix metalloproteinase 9 (MMP9) (29).