HHT treatment of GBM can inactivate STAT3 signaling by inhibiting PDGFRα phosphorylation and PDGFRα/Ras homolog family member A (RhoA)/Rho-associated coiled-coil-containing protein kinase (ROCK) axis to reduce glioblastoma cell proliferation, cytoskeletal remodeling, and migration (108). This evidence concerns the gene STAT3 and glioblastoma.