Sun et al. (2023) summarized the prebiotic effects of L. barbarum and suggested that LBP could prevent inflammatory bowel disease (IBD) through the growth of the intestinal microbiota and the production of metabolites, especially bile acids and short-chain fatty acids (SCFAs). Moreover, recent studies have shown that the anti-inflammatory effect of LBP is due to inhibiting the expression of proinflammatory factors, mitogen-activated protein kinase (MAPK)-mediated inflammatory cell signaling pathways, and nuclear factor kappa B (NF-κB) (Jin et al., 2013). Here, NFKB1 is linked to inflammatory bowel disease.