In regards to mechanism of action, our data suggest that LBP alleviates SM enteritis via the MAPK and Toll-like receptor (TLR) signaling pathway, and inhibits the expression of important genes MAP and NF-κB2 in the MAPK signaling pathway in response to the inflammatory alleviating effect of LBP. The gene discussed is NFKB2; the disease is systemic mastocytosis.