According to our results, the addition of LBP inhibited the expression of pro-inflammatory factors such as IL-1β, IL-17, IL-22, and IL-26, while promoting the expression of the tight junction protein-related gene Occludin. The expression of proinflammatory factors is directly related to the occurrence of intestinal inflammation, and reducing the expression of proinflammatory factor genes can significantly prevent the occurrence of inflammation. The gene discussed is OCLN; the disease is inflammatory response.