Decreased IL-6, TNF-α, IL-10, and IL-12 and increased IFN-γ, G-CSF, MIP-2 in lungs at 2 m.p.i. Larger lesions, higher bacterial counts and greater accumulation of neutrophils in the lung with high MPO+, resulting in faster mortality compared to WT after infection. The gene discussed is TNF; the disease is infection.