BHLHE40 and diabetes mellitus: The use of more susceptible strains and KO mouse mutants has led to discoveries of key immune mechanisms, such as trained immunity, the impact of metabolic co-morbidities (diabetes), and the early protection induced by specific soluble mediators (such as Cish, Parkin, Atg5, transcription factors like Bhlhe40, among others), eosinophils and receptors (CLECSF8).