Increased lung inflammation, bacterial counts at 4 m.p.i, and mortality. CLECSF8 recognizes TDM and is anti-mycobacterial in mice. Significant increase of neutrophil infiltration in lungs 48 h.p.i with BCG, H37Rv, or Beijing. All proinflammatory cytokines evaluated and IL-10 were significantly increased after infection with H37Rv, but only TNF-α, IFN-γ, and G-CSF after BCG infection. The gene discussed is CLEC4D; the disease is infection.