Upregulated in the first 2 weeks and then stayed downregulated in cases of ATB until week 6. This transcriptomic profile may be associated with increased apoptosis after 2 w.p.i. and stimulation of T cell response and an M2 phenotype.The upregulation of these genes was associated with ATB, some of them since 2-6 w.p.i compared to pre-infected stage. Additionally, Mauritian macaques were more susceptible to develop severe TB compared to the Chinese lineage. Downregulation of SOCS3, IRF4 and IFNβ1 with upregulation of IRF4 correlated with signs of disease. The gene discussed is IRF4; the disease is tuberculosis.