There was also a strong correlation between renal tissue iron overload with iNOS upregulation iNOs/Arg1 ratio, CD8+, CD68+, and CD163+ macrophage phenotype (Figures 8A–E), indicating the impacts of both iron overload and inflammatory macrophages on each other within 72 h of induction of sepsis. The gene discussed is NOS2; the disease is Sepsis.