It is also reported that CD163 was expressed in several kidney diseases related to the accumulation of hemoglobin in renal tissue, such as IgA nephropathy, macroscopic hematuria with AKI, paroxysmal nocturnal hemoglobinuria, and warm antibody hemolytic anemia (Fervenza et al., 2008; Ballarin et al., 2001). This evidence concerns the gene CD163 and paroxysmal nocturnal hemoglobinuria.