Additionally, phosphatase and tensin homolog (PTEN), a commonly mutated, deleted, or silenced tumor suppressor in numerous cancers, has been linked to the WWP1-PTEN axis in MYC-induced tumorigenesis and progression (Li et al., 1997; Bonneau and Longy, 2000; Lee et al., 2019). This evidence concerns the gene PTEN and neoplasm.