Mutations in GBA1, the most common PD risk gene encoding the lysosomal enzyme glucocerebrosidase (GCase), have been shown to cause suppression of CMA as a result of mislocalization of mutant GCase to the lysosomal surface, thereby causing α-synuclein aggregation (Kuo et al., 2022). The gene discussed is SNCA; the disease is Parkinson disease.