SNCA and Parkinson disease: As for PARK17 gene product VPS35 whose D620N mutation is associated with PD, LAMP2A-positive vesicles were reduced while α-synuclein-positive vesicles were increased in dopaminergic neurons from VPS35 knockout mice and D620N VPS35 overexpressing cells, due to enhanced degradation of LAMP2A in lysosomes (Tang et al., 2015).