HDAC6 (histone deacetylase 6) has been suggested to regulate the pathologies of synucleinopathies including PD (Lemos and Stefanova, 2020), possibly by deacetylating HSP90 that regulates α-synuclein degradation by CMA (Du et al., 2021). This evidence concerns the gene HDAC6 and synucleinopathy.