As for PARK17 gene product VPS35 whose D620N mutation is associated with PD, LAMP2A-positive vesicles were reduced while α-synuclein-positive vesicles were increased in dopaminergic neurons from VPS35 knockout mice and D620N VPS35 overexpressing cells, due to enhanced degradation of LAMP2A in lysosomes (Tang et al., 2015). Here, VPS35 is linked to Parkinson disease.