Additionally, the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) facilitates the degradation of the neurotoxic metabolite kynurenine, helping prevent stress-induced depression by regulating mitochondrial biogenesis and oxidative phosphorylation (21). The gene discussed is PPARGC1A; the disease is depressive symptom measurement.