THPO and Thrombocytopenia: To further confirm whether the increased thrombocyte counts observed after decitabine treatment was associated with changes in thpo expression, we conducted a decitabine administration experiment in thposzy6 zebrafish, a thrombocytopenia model characterized by a significant deficiency in thpo expression.14 Our findings are consistent with the results observed from mplsmu3 zebrafish, which showed that both wild-type siblings and thposzy6 zebrafish exhibited higher thrombocyte counts under the same treatment conditions (Fig. 1H and I).