After searching literature, we found that the lipid-lowering effects of baicalin (Yang H. et al., 2019; Xiang J. et al., 2019), quercetin (Zhang et al., 2019), atractylenolide (Li, et al., 2022), isorhamnetin (Huang et al., 2016), rhapontin (Wei et al., 2017) and ecsulin (Cheng et al., 2024) are related to the activating of AMPK/SIRT signaling pathway, which provides a basis for PCE to alleviate NASH by activating AMPK/SIRT1 pathway. This evidence concerns the gene SIRT1 and metabolic dysfunction-associated steatohepatitis.