SIRT1 and metabolic dysfunction-associated steatohepatitis: In view of the activation effect of PCE on AMPK/SIRT1 and to full evaluated the effect of PCE in alleviate NASH, the levels of interleukin-1β (IL-1β), IL-6, p65 and tumor necrosis factor-α (TNF-α) in mice liver tissue were tested by Western blot and qPCR.