HFD increased “Neutrophil degradation, cachexia signaling pathway, acute phase response signaling, post-translational protein phosphorylation, activation of SREBP, IL-4 and IL-13 signaling, cholesterol biosynthesis, response to elevated Ca2+, circadian gene expression”, etc. and PCE treatment attenuated or abolished such pathways. Here, IL13 is linked to Cachexia.