ZFAS1 enhances the formation of small nucleolar ribonucleoprotein (snoRNP) by synergistically recruiting snoRNAs, particularly SNORD12C and SNORD78, together with NOP58. This leads to an elevation in rRNA 2⁣′-O-methylation levels, which ultimately alters translational activity and precision of downstream target genes, thereby promoting CRC proliferation [121]. The gene discussed is NOP58; the disease is colorectal carcinoma.