Flow cytometry of tumor infiltrating immune cells also showed an increased trend of immunosuppressive myeloid cells and exhausted T cells as a result of anti-IL-1β monotherapy, but the combination of anti-IL-1β and anti-PD-1 reverses these changes in the PDAC model with lung metastasis tropism, but not in the model with liver metastasis tropism. Here, IL1B is linked to neoplasm.