IL1B and neoplasm: These findings suggest that the KPC-4545 orthotopic tumors may be sensitive to both anti-IL-1β and anti-PD-1 monotherapy in comparison to the KPC-3403 orthotopic tumor, as represented by how both treatments slowed tumor growth curve in the KPC-4545 model, but not the KPC-3403 model (Figs. 1B and 2A).