IL18 and neoplasm: As previously shown in the untreated KPC-4545 tumor (Tables S1-S4), IL-1 signaling, including IL-1ɑ, IL-1β, and IL-18, also appeared to be the dominant cytokine-type ligand-receptor interaction between macrophages/granulocytes and CAFs for the KPC-3403 model (Tables S1&S2).