Upon flow cytometry assessments 24 h later and based on CD138, PI, and Annexin staining, the primary CD138 + MM cells derived from patients with elevated serum LDH levels (N = 3) experienced relatively more late apoptosis/necrosis in a dose-dependent fashion compared to the primary CD138 + MM cells from patients with non-elevated serum LDH levels (N = 5) (Fig. 6C). The gene discussed is SDC1; the disease is Miyoshi myopathy.