KDM5C gene silencing leads to down-regulation of SCN2A, CACNA1B; CACNA1H; SCL4A3, SLC18A1, and SLC6A12 [9], All of these KDM5C target genes have been linked to neurological disorders such as epilepsy, autism or schizophrenia [30–36]. Here, CACNA1B is linked to epilepsy.