Transcription factor c-Jun binds with the PPP1R15A promoter with the potential binding sequences shown in Fig. 2F according to the prediction results of the JASPAR, and the expression levels of the two genes were positively correlated in the TCGA-stomach adenocarcinoma (STAD) database (r = 0.471, P < 0.001) (Fig. 2G). This evidence concerns the gene JUN and gastric adenocarcinoma.