Interestingly, in melanoma, GSK-3β negatively regulates the stabilization of microphthalmia-associated transcription factor (MITF) as well as the Wnt/β-catenin and PI3K/AKT pathways, which promote cancer cell survival, proliferation, and resistance to apoptosis [19, 34, 35]. The gene discussed is AKT1; the disease is melanoma.