C4B and cyclic hematopoiesis: Modeling LTL as a risk factor of CH revealed that longer genetically predicted LTL was associated with overall CH, as well as DNMT3A-CH and TET2-CH as previously reported15 (overall CH, beta = 0.029, 95% CI = [0.017, 0.041], P = 4.19 × 10−6; DNMT3A-CH, beta = 0.040, 95% CI = [0.023, 0.057], P = 5.10 × 10−6; TET2-CH, beta = 0.036, 95% CI = [0.014, 0.058], P = 1.43 × 10−3; Fig. 3c and Supplementary Table 12).