DNMT3A and cyclic hematopoiesis: At the nominally significant threshold (P < 0.05), it was also associated with an increased risk of six other gene-specific CH subtypes but a decreased risk of DNMT3A-CH (OR = 0.31, 95% CI = [0.18, 0.55], P = 1.44 × 10−6; Fig. 4b and Supplementary Table 15).