Only a mild attenuation in the association between European ancestry and CH risk was observed (overall CH, beta = 0.80, 95% CI = [0.60, 0.99] vs 0.73 [0.52, 0.94]; DNMT3A-CH, beta = 1.12, 95% CI = [0.84, 1.39] vs 1.02 [0.73, 1.32]; SRSF2-CH, beta = 2.17, 95% CI = [0.81, 3.52] vs 1.77 [0.31, 3.22] for the model without vs with LTL PRS as a covariate, respectively; Supplementary Table 13). This evidence concerns the gene SRSF2 and cyclic hematopoiesis.