DNMT3A and cyclic hematopoiesis: Consistent with this finding, we observed an increased risk of overall CH in an intra-population logistic regression with CH as the outcome and proportion of European genome (continuous variable) as the main predictor adjusted for age, sex and smoking (beta = 0.84, 95% CI = [0.66, 1.03], P = 7.35 × 10−19) and also with increased risk of DNMT3A-CH (beta = 1.15, 95% CI = [0.89, 1.41], P = 4.52 × 10−18), ASXL1-CH (beta = 1.55, 95% CI = [0.97, 2.14], P = 1.76 × 10−7) and SRSF2-CH (beta = 2.17, 95% CI = [0.88, 3.45], P = 9.64 × 10−4; Fig. 2d and Supplementary Table 9).