TTR and cholangiocarcinoma: Transcriptome analysis from CCA (Akt/Notch) and HCC (Myc/Trp53) mice corroborated these shifts—Prox1 knockdown in HCC caused downregulation of hepatocyte markers (for example, Alb and Ttr) and upregulation of cholangiocyte markers (for example, Krt19 and Sox9), while late Prox1 OE in CCA resulted in the opposite effect (Fig. 7e).