In most cases, taurine and taurine transport are renoprotective; taurine supplementation reduced blood pressure increases in Dahl Salt-Sensitive rats62, prior taurine administration reduced ischemia-reperfusion injury63, loss of TauT increased diabetic nephropathy susceptibility in streptozotocin-treated C57BL/6 mice64, and taurine transporter knockout mice had reduced diuresis after repeated water loads and increased vasopressin to creatinine ratios following water deprivation65. The gene discussed is SLC6A6; the disease is diabetic kidney disease.