CASP3 and dermatitis: To this regard, the study of the P38 and JNK kinases, both activated by ZAKα and already described as strong inducers of Caspase-3-dependent cell death during RSR, will be of importance in order to discriminate about their respective importance in Portimine-driven skin inflammation (Sinha et al, 2024; Robinson et al, 2023).