Since MDSCs have been shown to accumulate in hosts with advanced malignancies, suppress the antitumor immune response, and promote tumor progression (Almand et al, 2001; Ochoa et al, 2007; Ozao-Choy et al, 2009; Pan et al, 2008; Pan et al, 2008; Yang et al, 2013), we determined whether the function of MDSCs was altered due to CMTM4 KD, in addition to the immune composition being changed within the tumor environment. This evidence concerns the gene CMTM4 and neoplasm.