CMTM4 and neoplasm: Consistent with our previous publication demonstrating the role of MDSCs in Treg cell expansion in tumor-bearing mice (Huang et al, 2006a; Pan et al, 2010), we observed that Treg cells and the CD4 population were significantly reduced in CMTM4 KD tumors when compared to mice bearing control wild-type tumors (Fig. 6F).