While impairments in LEPR signaling increase susceptibility to early-onset obesity, hyperphagia, insulin resistance, and infertility in humans3, db/db mice35, and fa/fa rats36, we do not observe effects of mutations in lepr on any adiposity-related trait in 10-day-old overfed zebrafish larvae (Fig. 2, Supp Fig. 13, Supp Table 10). The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.