Secondly, larvae with CRISPR/Cas9-induced mutations in agrp (n = 59) are at higher risk of being in Q1 vs. Q2 than sibling controls (n = 34), in line with agouti-related protein’s anticipated orexigenic activity, as well as with overexpression of agrp in adult zebrafish resulting in obesity, increased growth and adipocyte hypertrophy58. The gene discussed is AGRP; the disease is obesity due to melanocortin 4 receptor deficiency.