CF is an autosomal recessive disorder characterized by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.310 Mutations in CFTR lead to altered sodium and chloride permeability on the cellular epidermis,311,312 and abnormal mucus secretion.313 In the pancreas, this manifests as blockage of the ducts by abnormal mucus secretion, limiting the release of digestive enzymes and leading to dyspepsia. This evidence concerns the gene CFTR and dyspepsia.