ADM and diabetes mellitus: Adrenomedullin and vanin-1 are carried by exosomes in many inflammatory responses, possibly taking part in β cell dysfunction in CP-related DM and PDAC-DM.364–366 Pro-inflammatory cytokines such as IL-10 and IL-12 need more studies to confirm their functions in β cell dysfunction to better distinguish CP-related DM from T1D and T2D.