SST and Alzheimer disease: A unique feature of SST is its ability to enhance the activity of Aβ-degrading enzymes in the brain through receptor-mediated actions.539 Studies have shown that activation of SSTR2 can inhibit the production and deposition of amyloid-beta, suggesting that restoring SSTR2 function may have protective effects against AD.536,540 Somatostatin-based therapeutic strategies could offer new approaches to slowing the progression of AD.