In additional primary human NSCLC cells (pNSCLC-2 and pNSCLC-3), as well as in the immortalized A549 cells, the creation of stable MTCH2 knockdown through the use of the shMTCH2-S1-expressing lentiviral particles (see Fig. 4) similarly induced Caspase-3 activation (Fig. 5J) and elevated the number of nuclei exhibiting positive TUNEL staining (Fig. 5K), thus affirming the induction of apoptosis. The gene discussed is MTCH2; the disease is non-small cell lung carcinoma.