MTCH2 and non-small cell lung carcinoma: In additional primary human NSCLC cells (pNSCLC-2 and pNSCLC-3), as well as in the immortalized A549 cell line, the establishment of stable MTCH2 knockdown using the shMTCH2-S1-expressing lentiviral vector (see Figs. 4 and 5) similarly resulted in a significant decrease in mitochondrial complex-I activity (Fig. 6G) and cellular ATP levels (Fig. 6H).