In a multivariable model including age at diagnosis, T stage, clinical nodal status, and tumor grade, RCB index remained significantly associated with shorter EFS among the ILC cohort overall (HR 1.82, 95% CI 1.23–2.68, p = 0.003), but in the smaller subset of HR+HER2- ILC cases the trend towards shorter EFS persisted but no longer reached statistical significance (HR 1.53, 95% CI 1.0–2.44, p = 0.077) (Table 4). The gene discussed is ERBB2; the disease is neoplasm.