The results demonstrated that the silencing of HIF2α or MCJ mitigated the tube formation induced by the conditioned medium from ccRCC cells, and this effect could be rescued by the overexpression of MCJ (Fig. 6E), without affecting the viability of HUVEC (Supplementary Fig. 3A, B). This evidence concerns the gene DNAJC15 and nonpapillary renal cell carcinoma.