DNASE1 and Autoimmunity: However, DNASE1L3 has been found to have broader substrates such as DNA complexed in microparticles of proteins and lipids.5 39 Despite the complementary functions of DNASE1 and DNASE1L3, the deficiency of DNASE1L3 results in overt autoimmunity that is not compensated for by DNASE1.2