Moreover, NEC mice in contrast with control mice exhibited elevated expressions of IL-1β and IL-6 in their ileum (Fig. 1M-1N, p < 0.001); however, the elevation of the level of these inflammatory cytokines weakened with DS0384 gavage (Fig. 1M-1N, p < 0.001). This evidence concerns the gene IL6 and necrotizing enterocolitis.