Cell origin–focused glycoproteomics enabled using the well-curated Human Protein Atlas combined with immunohistochemistry of CRC tumor tissues recapitulated these findings and indicated that the paucimannosidic proteins were in part from tumor-infiltrating monocytes (e. g., MPO, AZU1) and of CRC cell origin (e. g., LGALS3BP, PSAP). Here, AZU1 is linked to colorectal carcinoma.