HEXB and colorectal carcinoma: In line with the observation that HEXB dominates in CRC TUMs and PBMCs (Supplemental Fig. S3, A and B, and Fig. 3, A and B), the activity of HEXB (measured as MUG-MUGS) was found to be the principal Hex isoenzyme form in CRC plasma (Supplemental Fig. S3C).