As HEXB (not HEXA) expression in this present study was found to be elevated in CRC tissues from a large patient cohort and the fact that the HEXA protein level appeared insignificant in the investigated CRC specimens (Fig. 3, A and B, and Supplemental Fig. S3, A and B), we focused the downstream investigation on HEXB. The gene discussed is HEXB; the disease is colorectal carcinoma.