F8A2 and COVID-19: Biologically, genetic variations in immune response pathways may influence susceptibility to severe outcomes, with significant differences in inflammatory markers and gene expression patterns in COVID-19-related pathways, such as interleukin-1 beta and genes like glutathione S-transferase M1, C-C motif chemokine ligand 3 like 3, and coagulation factor VIII associated 2 [57,58].