CDK12 and breast neoplasm: Indeed, we saw a 5.4-fold increase in RNAPII-S5p over the CCNK promoter in the breast tumor relative to adjacent normal tissue, whereas in the colon tumor there is a 2.1-fold increase (Fig. 2J), and a 0.9–2.5-fold increase for the other five tumors, consistent with RNAPII hypertranscription driven in part by CDK12 amplification in this tumor.