The pentose phosphate pathway converts glucose-6-phosphate into pentoses and generates ribose-5-phosphate and NADPH thereby governing anabolic biosynthesis and redox homeostasis, generate fuels NOX2 to reduce reactive oxygen species which ameliorate the inflammatory response [22], the non-oxidative pentose phosphate pathway was reported to regulate regulatory T function to prevent autoimmunity [23]. The gene discussed is CYBB; the disease is Autoimmunity.