Similarly, α-SMA expression and collagen content, representing myofibroblastic CAFs, were decreased in HFD-fed Has2ΔHSC mice compared with HFD-fed WT mice (Figure 2E), suggesting that HAS2 is crucial for developing myofibroblastic CAFs and collagen production in tumor lesions when coexistent with steatotic liver. This evidence concerns the gene HAS2 and neoplasm.