In HFD-fed mice, 4-MU and 4-MUG treatment significantly inhibited tumor growth, HA deposition (by HA-binding protein [HABP] staining), collagen content (by Sirius red staining, mRNAs, and protein), and myofibroblastic CAFs (by α-SMA immunostaining, mRNA, and protein) (Figure 7, B–F, and Supplemental Figure 7, A–C). This evidence concerns the gene ACTA1 and neoplasm.