Similarly, α-SMA expression and collagen content, representing myofibroblastic CAFs, were decreased in HFD-fed Has2ΔHSC mice compared with HFD-fed WT mice (Figure 2E), suggesting that HAS2 is crucial for developing myofibroblastic CAFs and collagen production in tumor lesions when coexistent with steatotic liver. The gene discussed is ACTA1; the disease is neoplasm.