Moreover, our findings suggest a role for MECP2 disruption in the response to IL-1beta and other cytokines that might be unrelated to IRAK1 because we noted a decreased response to IL-1beta, IL-6, and IL-8 in cells with MECP2 LOF but intact IRAK1. This potential role of MECP2 LOF (but not duplication) in immune regulation would be consistent with the lack of abnormal levels of IL-6 and/or IL-8 in individuals with MRXSL (Fig. 5). Here, IL6 is linked to syndromic X-linked intellectual disability Lubs type.