IRAK1 (Interleukin 1 Receptor-Associated Kinase 1) encodes a serine/threonine kinase of the proinflammatory cytokine interleukin-1 receptor (IL-1R) and is thought to potentially play a role in the inflammatory responses seen in patients with MRXSL (Bauer et al. 2015). This evidence concerns the gene IRAK1 and syndromic X-linked intellectual disability Lubs type.