NFKB1 and cardiovascular disorder: Saturated fatty acids such as stearic acid (C18:0) are known contributors to the development of cardiovascular diseases, and stearic acid in particular has been described to mediate pro-inflammatory effects and cell growth inhibition in human aortic endothelial cells via upregulation of intercellular adhesion molecule-1 (ICAM-1), which regulates leukocyte recruitment to the site of inflammation [61], and the induction of nuclear factor-kappa B (NF-κB) signaling [62].