With respect to BCP-ALL, B cells in patients with KMT2A fusion, ETV6::RUNX1/-like, hyperdiploidy, BCR::ABL1/Ph-like, PAX5 and CRLF2 fusion, PAX5 (p.P80R) mutation, ZNF384 fusion, or DUX4 fusion were blocked mainly at the pre-pro-B and early-pro-B stages (Figure 4F, Figure S4C). The gene discussed is CRLF2; the disease is acute lymphoblastic leukemia.