We replicated these findings in a second cohort of 48 primary prostate cancer tumors profiled via ChIP-seq for H3K27ac, H3K4me2, H3K4me3, FOXA1, and HOXB13 (Supplementary Fig. S12A and S12E; Supplementary Table S9). Here, HOXB13 is linked to Familial prostate cancer.