Additionally, in ourpatients with RTH, the strong influence of the THRB1 gene expression on hearinglosses of cochlear origin is supported by the lack of changes in the electricalconduction of the acoustic signal in the central auditory pathways, as demonstratedby typical ABR results, which may exclude the hypothesis of retrocochlear hearingloss as the primary factor associated with hearing loss (6). The gene discussed is THRB; the disease is thyroid hormone resistance syndrome.