In contrast, central nervous system (CNS)hemangioblastomas (HBs) (90.47% vs. 53.12%; p = 0.004),pancreatic cysts (76.19% vs. 28.12%; p = 0.001) and RCCs(57.14% vs. 12.5; p = 0.001) were more common in patientswith non-missense VHL variants. This evidence concerns the gene VHL and hemangioblastoma.