Investigation into the ICD‐related gene interferon gamma (IFNG) showed that its overexpression in LUAD cells enhances CRT exposure, promotes HMGB1 and ATP release, strengthens ICD, facilitates dendritic cell (DCs) maturation, enhances CD8+ T cell function, and promotes tumor angiogenesis dependent on HMGB1. This evidence concerns the gene HMGB1 and neoplasm.