In two patients with SLD and hyperferritinemia, a diagnosis of HFE‐related hemochromatosis was reached, due to compound heterozygosity for p.C282Y/p.H63D variants in HFE gene in one patient (#7) and to p.C282Y homozygosity in the other one (#8), accounting for their phenotype characterised by high ferritin levels with high transferrin saturation (300 ng/mL and 67%, respectively, in the first patient and 2189 ng/mL and 86% in the second one). This evidence concerns the gene TF and hemochromatosis.