We previously developed a polygenic risk score for SLD (SLD‐PRS, previously referred to as PRS‐5), based on the combination of common variants in five genes (PNPLA3, TM6SF2, GCKR, MBOAT7 and HSD17B13), capturing the genetic predisposition to develop a form of SLD at higher risk of hepatic complications, including cirrhosis, hepatocellular carcinoma (HCC) and liver events [20]. The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.