Three individual variants showed a significant association with liver traits: besides the low‐frequency SERPINA1 rs28929474 (PiZ allele), a main genetic determinant of liver disease, [24] we identified ABCB4 rs375315619 and APOB rs12691202, supporting their role in phenotype determination (Table S4 and Data S1: Results). The gene discussed is ABCB4; the disease is liver disorder.