In particular, we focused on the ligands PhenDC3 and PDS that are widely used phenanthroline and quinoline derivatives, respectively [17], and the NDI derivatives CM03 and QN-302 that have been recently reported to show significant anti-tumour activity in in vitro and in vivo models of pancreatic cancer [18, 20, 21, 24, 40]. This evidence concerns the gene AVPR2 and familial pancreatic carcinoma.