The classification criteria for APS require aPL tests, including lupus anticoagulant (LA), IgG/IgM anticardiolipin antibodies (aCL), and/or IgG/IgM anti‐β 2‐glycoprotein‐1 antibodies (aβ2GP‐1), present on two or more occasions, at least 12 weeks apart [3, 4]. This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.